Genital Ulcer & STD Expanded Panel
Test Overview
The Genital Ulcer and STD Expanded Panel is a comprehensive diagnostic tool designed to detect the most common causes of genital ulcers and sexually transmitted infections (STIs). It uses advanced PCR (Polymerase Chain Reaction) technology for precise detection, ensuring faster and more accurate results than traditional methods.
Conditions and Pathogens Detected
Viral Infections:
- Herpes Simplex Virus 1 (HSV-1)
- Herpes Simplex Virus 2 (HSV-2)
- Varicella-Zoster Virus (VZV) – Rare cause of genital ulcers
- Human Papillomavirus (HPV) – For wart-like lesions, not typical ulcers
- Cytomegalovirus (CMV) – Rare in immunocompetent individuals
Bacterial Infections:
- Treponema pallidum (Syphilis) – Detects the DNA of syphilis-causing bacteria
- Haemophilus ducreyi (Chancroid) – Causes painful genital ulcers
- Klebsiella granulomatis (Donovanosis/Granuloma inguinale)
- Mycoplasma genitalium – Often linked to urethritis and cervicitis
- Chlamydia trachomatis (Lymphogranuloma venereum – LGV strains)
Parasitic Infection:
- Trichomonas vaginalis – Common STI that may contribute to genital irritation and ulcers
Symptoms That May Require This Panel
- Painful or painless genital ulcers
- Unusual discharge or foul odor
- Burning sensation during urination
- Genital redness, swelling, or irritation
- Swollen lymph nodes in the groin
- Painful intercourse
- Fever, fatigue, or general malaise (associated with systemic STIs)
Sample Collection
- Sample Type: Lesion swab, genital swab, or urine sample (depending on suspected infection)
- Container: Sterile swab in transport medium or sterile urine container
- Collection Tips: Avoid sexual intercourse for at least 24 hours prior to collection. Do not cleanse the area before sampling to preserve pathogen DNA. For ulcers, swab the base of the lesion where viral or bacterial DNA is concentrated
Result Interpretation
| Test Component: | Normal (Negative): | Abnormal (Positive): |
|---|---|---|
| HSV-1 / HSV-2 | Not Detected | Detected – Confirms Herpes Infection |
| Treponema pallidum (Syphilis) | Not Detected | Detected – Confirms Syphilis |
| Haemophilus ducreyi (Chancroid) | Not Detected | Detected – Confirms Chancroid |
| Klebsiella granulomatis (Donovanosis) | Not Detected | Detected – Suggests Granuloma inguinale |
| Chlamydia trachomatis (LGV strains) | Not Detected | Detected – Suggests LGV |
| Trichomonas vaginalis | Not Detected | Detected – Confirms Trichomoniasis |
| Mycoplasma genitalium | Not Detected | Detected – Indicates STI or genital irritation |
Treatment Guidance Based on Results
- Herpes Simplex Virus (HSV-1 or HSV-2) → Antiviral therapy (Acyclovir, Valacyclovir)
- Syphilis (Treponema pallidum) → Penicillin G (First-line treatment)
- Chancroid (Haemophilus ducreyi) → Azithromycin or Ceftriaxone
- Donovanosis (Klebsiella granulomatis) → Azithromycin (prolonged treatment)
- Lymphogranuloma venereum (Chlamydia trachomatis – LGV strains) → Doxycycline (21-day course)
- Trichomoniasis (Trichomonas vaginalis) → Metronidazole or Tinidazole
Turnaround Time
- PCR Panel Results: 24–48 hours
- Syphilis serology or additional confirmatory tests: 2–5 days
Why Choose the Genital Ulcer & STD Expanded Panel?
- Comprehensive coverage for viral, bacterial, and parasitic causes
- Fast results with PCR technology for precise detection
- Ideal for patients with recurrent, persistent, or unexplained genital symptoms
- Helps guide targeted treatment for faster recovery