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C-Reactive Protein

Test Overview

The C-Reactive Protein (CRP) test measures the level of CRP, a protein produced by the liver in response to inflammation. CRP levels rise when there is infection, inflammation, or tissue injury in the body. This test is commonly used to detect and monitor conditions such as infections, autoimmune diseases, and chronic inflammatory disorders.

Test Uses

  • Detects acute and chronic inflammation.
  • Helps diagnose and monitor infections, autoimmune diseases (e.g., rheumatoid arthritis, lupus), and inflammatory conditions (e.g., Crohn’s disease, vasculitis).
  • Assesses recovery from surgery, injury, or infection.
  • Evaluates the risk of cardiovascular disease when used as a high-sensitivity CRP (hs-CRP) test.

CRP Test Results & Ranges

Test Component:Normal Range:Elevated (Indicates Inflammation):
C-Reactive Protein (CRP)< 1.0 mg/dL1.0 – 10.0 mg/dL (Mild to moderate inflammation)
>10.0 mg/dL (Significant inflammation, possible acute infection or chronic disease)

Interpreting Abnormal CRP Levels:

  • Mild Elevation (1.0 – 3.0 mg/dL):

    • May indicate low-grade inflammation, possibly due to obesity, smoking, or early chronic disease.

  • Moderate Elevation (3.0 – 10.0 mg/dL):

    • Chronic inflammatory conditions (e.g., rheumatoid arthritis, inflammatory bowel disease).
    • Viral or mild bacterial infections.

  • High Elevation (>10.0 mg/dL):

    • Severe infections (bacterial pneumonia, sepsis).
    • Autoimmune diseases (e.g., lupus, rheumatoid arthritis, vasculitis).
    • Acute inflammation from surgery, trauma, or severe tissue damage.

  • Extremely High Levels (>50 mg/dL):

    • Suggests severe infections, burns, or sepsis requiring immediate medical attention.

 

Expected Turnaround Time

  • Results Available: Typically within 24 hours.

Specimen Requirements

  • Sample Type: Blood sample (venipuncture).
  • Container: Serum separator tube (SST, gold-top tube).

Collection Instructions

  • Fasting is not required.
  • Avoid intense exercise before the test, as it can temporarily elevate CRP levels.
  • Inform your doctor if you have an infection, injury, or chronic condition that may affect the results.

Test Details

Clinical Use: Evaluates inflammation and its causes. Monitors treatment response in chronic inflammatory diseases. Used as a marker for infection, autoimmune conditions, and cardiovascular disease risk (hs-CRP version).

Limitations: CRP is a general marker of inflammation and does not specify the cause—additional tests may be needed for diagnosis. Medications (e.g., statins, anti-inflammatory drugs) may lower CRP levels.

The CRP Test is essential for detecting and monitoring inflammation, infections, and autoimmune diseases, helping guide diagnosis and treatment.

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